M.D. Anderson Research Publications:

Anti Cancer
Anvirzel™, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.

Cancer Research, (2 articles)
Cardiac Glycosides Stimulate Ca2+ Increases and Apoptosis in Androgen-independent, Metastatic Human Prostate Adenocarcinoma Cells.

Oleandrin Suppresses Activation of Nuclear Transcription Factor KB, Activator Protein-1, and C-Jun NH2-Terminal Kinase.

Analytical Chemistry
LC/MS/MS Analyses of an Oleander Extract for Cancer Treatment.

Journal of Herbal Pharmacotherapy
Composition and Preliminary Pharmacology Studies with Anvirzel™: An Extract of Nerium oleander.

Biochemical Pharmacology
Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel™ and its cardiac glycoside component, oleandrin.

Cancer Letters
Enhancement of radiotherapy by oleandrin in a caspase-3 dependent process.

Journal of Experimental Therapeutics and Oncology
Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.

Journal of Experimental Therapeutics and Oncology
Oleandrin - Mediated oxidative stress in human melanoma cells.

Integrative Cancer Therapies
6(4); 2007; Kondo, Y.; Newman, R.A., et al. Autophagic Cell Death of Human Pancreatic Tumor Cells Mediated by Oleandrin, a Lipid-Soluble Cardiac Glycoside.

Molecular Interventions
6(1) 2008; Newman, R.A., et al. Cardiac Glycosides as Novel Cancer Therapeutic Agents. (An invited review);

Molecular Cancer Therapies
8(8) 2009;Yang, P.; Newman, R. A., et al. Oleandrin-mediated Inhibition of Human Tumor Cell Proliferation: Importance of Na, K-ATPase a Subunits as Drug Targets.

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